VHI wmm Final

Run with ORIGIN

ORIGIN is very excited to be taking part in the Vhi Women’s Mini Marathon 2022 on June 5th in Dublin, Ireland. The Vhi Women’s Mini Marathon, an annual 10k charity road race in Dublin, is the largest Women’s event of its kind in the world. ORIGIN is delighted to have this opportunity to raise awareness of gynaecological cancer, promote women in STEMM and crucially, raise much needed funds for the Irish Cancer Society.

The Irish Cancer Society is a fantastic charity who are dedicated to transforming the experiences and outcomes of people affected by cancer through advocacy, support services and research. If you can, please donate to ORIGIN’s fundraising project on GivenGain!.

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ORIGIN at IEEE NSS MIC 2021

ORIGIN was selected for two oral presentations and a poster at the 2021 Virtual IEEE Nuclear Science Symposium and Medical Imaging Conference. Simone Cometti and Agnese Giaz from the University presented “characterization of scintillating materials in use for brachytherapy fiber-based dosimeters” and “First results of oncological brachytherapy fiber dosimeter”, respectively.

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ORIGIN researcher Mr Peter Woulfe appointed to Ireland’s first National Research Ethics Committee for Medical Devices

The remit of the NREC-MD is to review the submission of ethics applications related to Clinical Investigations of Medical Devices. The NREC-MD is one of three NRECs who’s membership was recently appointed by Minister for Health, Stephen Donnelly.https://www.nrecoffice.ie/members-appointed-to-irelands-first-nrecs-for-clinical-trials-and-medical-devices/

origin project

ORIGIN features in the Spring edition of the University of Limerick magazine – UL Links

A new project led by researchers at University of Limerick has the potential to dramatically reduce the risk of error in the treatment of prostate and gynaecological cancer

Origin aims to deliver more effective, photonics-enabled, brachytherapy cancer treatment through advanced real-time radiation dose imaging and source localisation.

A new optical fibre based sensor system to support diagnostics-driven therapy through enhanced adaptive brachytherapy will be developed through the project, of which University of Limerick is the coordinating organisation.

It brings together leaders from academia and industry to develop a new multi-point optical fibre based dose-monitoring system for both low dose rate and high dose rate brachytherapy, with novel algorithms to provide 3D dose imaging with source localisation capability.

The project has been awarded grant funding of almost €5m from the European Union’s Horizon 2020 Research and Innovation Programme, of which UL has received close to €1m.

Dr Sinéad O’Keeffe of UL, who is principal investigator on the project, explains more on the project. 

 The Origin system will be integrated into existing clinical brachytherapy treatment planning and delivery systems to confirm that the dose prescribed to the tumour is achieved, whilst ensuring the dose to organs at risk is within acceptable limits. 

Brachytherapy is a form of radiotherapy where radiation is administered internally. It is divided into Low Dose Rate (LDR), where the radioactive sources, known as seeds, remain implanted permanently in the patient, and High Dose Rate (HDR), where higher activity radiation sources are temporarily implanted.

Correct placement of the radiation source is vital to ensure adequate radiation to the target area (tumour), while ensuring minimum exposure to nearby critical organs, such as, in the case of prostate and gynaecological cancers, the bladder, urethra and rectal wall.

Optical fibres provide an ideal solution to true in vivo (i.e. internal to the body) volumetric dosimetry due to their small size, flexibility and electrical passiveness. 

Optical fibre sensors offer numerous advantages over conventional dosimeters, such as thermo-luminescence detectors and diodes. The most significant feature of an optical fibre dosimeter is that the dose information is transmitted using optical signals as opposed to electrical signals and that these optical signals can be remotely collected. This ensures the utmost safety for the patient and medical staff in conducting in-patient in vivo dosimetry.

The project will progress the development of optical fibre based sensors capable of measuring true in vivo radiation levels during treatment to provide for dose mapping and radiation source localisation capabilities.

The optical fibre radiation dosimeters will be further optimised for improved optical signal collection efficiency, higher signal-to-noise ratio and repeatable high volume fabrication… it will ensure that Origin establishes Europe at the forefront of brachytherapy system development and photonics manufacturing.

The Optical Fibre Dose Imaging for Adaptive Brachytherapy (ORIGIN) project is an initiative of the Photonics Public Private Partnership (www.photonics21.org), and has received funding from the European Union’s Horizon 2020 Research and Innovation Programme.

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ORIGIN partners presented their work plan

ORIGIN partners each presented their work plan for the next 6 months of ORIGIN during the project kick-off meeting held in the University of Limerick (Feb 6-7, 2020).

Discussions included the fibre optic radiation probes, optical fibre system, clinical integration of the ORIGIN device, 3D printing of phantom models and future marketing, exploitation and regulatory assessment.